Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma
Abstract
Aim: Differential pulse polarography was used for the concurrent analysis of the coadministered dantrolene (DAN) and indomethacin (IND) in plasma. Materials & methods: DAN and IND, Hanging mercury drop electrode and Britton–Robinson buffer at pH 5 were used. In plasma, cathodic reduction of DAN nitro group and its active metabolite at -0.2 V was done. IND was analyzed after carbonyl group reduction at -1.1 V. Results: Drugs determination in...
Paper Details
Title
Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma
Published Date
Jan 1, 2019
Journal
Volume
11
Issue
2
Pages
73 - 84
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