Chemistry

Inflammation

Curcumin

PI3K/AKT/mTOR pathway

Synovial membrane

Cancer research

Biochemistry

Pathogenesis

Apoptosis

Hyperplasia

Proinflammatory cytokine

Rheumatoid arthritis

Polyarthritis

Internal medicine

Pharmacology

Immunology

Arthritis

Medicine

Drug Design Development and Therapy

Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by aggressive and symmetric polyarthritis. Mammalian target of rapamycin (mTOR) was reported to be a new target for RA therapy and its inhibitor rapamycin can significantly reduce the invasive force of fibroblast-like synoviocytes. Here, we determined the effect of curcumin to alleviate inflammation and synovial hyperplasia for the therapy of RA.

Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats