Effect of curcumine on the formation of epidural fibrosis in an experimental laminectomy model in rats

To clarify the effects of topical application of curcumin on the prevention of epidural fibrosis.Twenty-one rats were randomly divided into three equal groups (control, spongostan, local curcumin) and a laminectomy procedure was performed between T11 and L1 in all rats. Subsequently, spongostan soaked with curcumin (100 mg/kg) was applied topically. After four weeks, the vertebral column from T9 to L3, which included the paraspinal muscles and...