Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer

Background Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells. Methods To investigate the mechanism underlying alternol‐induced cancer cell‐specific killing effect, we took a comprehensive strategy to identify Alternol's protein targets in prostate cancer cells, including PC‐3, C4‐2, and 22RV1, plus benign...