Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer
Abstract
Background Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells. Methods To investigate the mechanism underlying alternol‐induced cancer cell‐specific killing effect, we took a comprehensive strategy to identify Alternol's protein targets in prostate cancer cells, including PC‐3, C4‐2, and 22RV1, plus benign...
Paper Details
Title
Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer
Published Date
Jan 20, 2019
Journal
Volume
79
Issue
6
Pages
628 - 639
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