Rational Design of Cell-Active Inhibitors of PARP10

Volume: 10, Issue: 1, Pages: 74 - 79
Published: Nov 29, 2018
Abstract
Poly-ADP-ribose polymerases (PARPs 1–16) have emerged as major regulators of diverse cellular processes. PARPs can be subclassified based on their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). While much is known about the cellular roles of PARPs that catalyze PARylation (e.g., PARP1), the function of PARPs that catalyze MARylation (e.g., PARP10) is substantially less understood. This is due in...
Paper Details
Title
Rational Design of Cell-Active Inhibitors of PARP10
Published Date
Nov 29, 2018
Volume
10
Issue
1
Pages
74 - 79
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