Role of Treponema pallidum hemagglutination assay for diagnosis of syphilis in low titers of VDRL-reactive sera: A prospective study from a large tertiary care center of East Delhi

Sir, Since many decades, serological tests remained the keystone for diagnosis of syphilis. Venereal Disease Research Laboratory (VDRL) test is performed solely to screen patients for syphilis, and it still has remained unchallenged due to its simplicity, high sensitivity, and cost-effectiveness. However, serologic tests such as VDRL provide only indirect evidence of syphilis and may be reactive in the absence of clinical evidence of syphilis,...