Single event visualization of unconventional secretion of FGF2
Abstract
FGF2 is exported from cells by an unconventional secretory mechanism. Here, we directly visualized individual FGF2 membrane translocation events at the plasma membrane using live cell TIRF microscopy. This process was dependent on both PI(4,5)P2–mediated recruitment of FGF2 at the inner leaflet and heparan sulfates capturing FGF2 at the outer plasma membrane leaflet. By simultaneous imaging of both FGF2 membrane recruitment and the appearance of...
Paper Details
Title
Single event visualization of unconventional secretion of FGF2
Published Date
Nov 23, 2018
Journal
Volume
218
Issue
2
Pages
683 - 699
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