Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study.

Published on Nov 20, 2018in Diagnostic Pathology2.335
· DOI :10.1186/S13000-018-0771-3
Takashi Murakami10
Estimated H-index: 10
(Juntendo University),
Yoichi Akazawa9
Estimated H-index: 9
(Juntendo University)
+ 6 AuthorsTakashi Yao63
Estimated H-index: 63
(Juntendo University)
Sources
Abstract
Background Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular biological features of SSA/Ps with early neoplastic progression have not yet been fully elucidated, owing to the rarity of cases of SSA/P with advanced histology such as cytologic dysplasia or invasive carcinoma. In this study, we aimed to elucidate the molecular biological features of SSA/Ps with dysplasia/carcinoma, representing relatively early stages of the serrated neoplasia pathway.
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