Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Abstract
Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic diseases, including cancer, diabetes, and heart failure. However, an integrated understanding of whole-body BCAA metabolism remains lacking. Here, we employ in vivo isotopic tracing to systemically quantify BCAA oxidation in healthy and insulin-resistant mice. We find that most tissues rapidly oxidize BCAAs into the tricarboxylic acid (TCA) cycle, with the greatest...
Paper Details
Title
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Published Date
Feb 1, 2019
Journal
Volume
29
Issue
2
Pages
417 - 429.e4
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History