Cellular metabolism constrains innate immune responses in early human ontogeny
Abstract
Pathogen immune responses are profoundly attenuated in fetuses and premature infants, yet the mechanisms underlying this developmental immaturity remain unclear. Here we show transcriptomic, metabolic and polysome profiling and find that monocytes isolated from infants born early in gestation display perturbations in PPAR-γ-regulated metabolic pathways, limited glycolytic capacity and reduced ribosomal activity. These metabolic changes are...
Paper Details
Title
Cellular metabolism constrains innate immune responses in early human ontogeny
Published Date
Nov 16, 2018
Journal
Volume
9
Issue
1
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