A model for RAS mutation patterns in cancers: finding the sweet spot
Abstract
The three RAS genes - HRAS, NRAS and KRAS - are collectively mutated in one-third of human cancers, where they act as prototypic oncogenes. Interestingly, there are rather distinct patterns to RAS mutations; the isoform mutated as well as the position and type of substitution vary between different cancers. As RAS genes are among the earliest, if not the first, genes mutated in a variety of cancers, understanding how these mutation patterns...
Paper Details
Title
A model for RAS mutation patterns in cancers: finding the sweet spot
Published Date
Nov 12, 2018
Journal
Volume
18
Issue
12
Pages
767 - 777
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