SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
Abstract
One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glycine and formate. In a CRISPR-based genetic screen in human cells for genes of the mitochondrial pathway, we found sideroflexin 1 (SFXN1), a multipass...
Paper Details
Title
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
Published Date
Nov 16, 2018
Journal
Volume
362
Issue
6416
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