Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide approaches. We performed a genome-wide association study (GWAS) and polygenic risk score analysis in a Greek sample collection (GOMAP) comprising three patient groups: SCZ only ( n = 924), T2D only ( n = 822), comorbid SCZ and T2D...