Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy

Volume: 170, Issue: 2, Pages: 74 - 79
Published: Mar 1, 2019
Abstract
Abnormal blood vessels and hypoxic and necrotic regions are common features of solid tumors and related to the malignant phenotype and therapy resistance. Certain obligate or facultative anaerobic bacteria exhibit inherent ability to colonize and proliferate within solid tumors in vivo. Escherichia coli Nissle 1917 (EcN), a non-pathogenic probiotic in European markets, has been known to proliferate selectively in the interface between the viable...
Paper Details
Title
Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy
Published Date
Mar 1, 2019
Volume
170
Issue
2
Pages
74 - 79
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