Vasculitis

Inflammation

Acute tubular necrosis

Lupus nephritis

Fibrinoid necrosis

Disease

Kidney

Acute kidney injury

Neutrophil extracellular traps

Proinflammatory cytokine

Internal medicine

Pathology

Immunology

Medicine

Kidney International

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent.

Extracellular traps in kidney disease