Quantum mechanics

Magnetic field

Nanoparticle

Magnetization

Materials science

Magneto

Operating system

Computer science

Hyperthermia

Drug delivery

Physics

Plasmonic nanoparticles

Nanotechnology

Hot spot (computer programming)

Magnetic hyperthermia

Superparamagnetism

Photothermal therapy

Internal medicine

Plasmon

Medicine

Optoelectronics

Magnet

Magnetic nanoparticles

Advanced Drug Delivery Reviews

Magnetic hyperthermia which exploits the heat generated by magnetic nanoparticles (MNPs) when exposed to an alternative magnetic field (AMF) is now in clinical trials for the treatment of cancers. However, this thermal therapy requires a high amount of MNPs in the tumor to be efficient. On the contrary the hot spot local effect refers to the use of specific temperature profile at the vicinity of nanoparticles for heating with minor to no long-range effect. This magneto-thermal effect can be exploited as a relevant external stimulus to temporally and spatially trigger drug release. In this review, we focus on recent advances in magnetic hyperthermia. Indirect experimental proofs of the local temperature increase are first discussed leading to a good estimation of the temperature at the surface (from 0.5 to 6 nm) of superparamagnetic NPs. Then we highlight recent studies illustrating the hot-spot effect for drug-release. Finally, we present another recent strategy to enhance the efficacity of thermal treatment by combining photothermal therapy with magnetic hyperthermia mediated by magneto-plasmonic nanoplatforms.

Recent insights in magnetic hyperthermia: From the “hot-spot” effect for local delivery to combined magneto-photo-thermia using magneto-plasmonic hybrids