Effects of caffeine on intraocular pressure are subject to tolerance: a comparative study between low and high caffeine consumers

Caffeine has a well-established effect on intraocular pressure (IOP) and ocular perfusion pressure (OPP); however, the possible differences between low- and high-caffeine consumers remain unknown. In this placebo-controlled, double-blind, and balanced crossover study, 40 healthy individuals were divided in low- (n = 21) and high (n = 19)-caffeine consumers, according to their daily caffeine consumption. All participants ingested either caffeine...