2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Published on Jun 25, 2019in Circulation23.603
· DOI :10.1161/CIR.0000000000000625
Scott M. Grundy212
Estimated H-index: 212
Neil J. Stone56
Estimated H-index: 56
+ 21 AuthorsJoseph Yeboah29
Estimated H-index: 29
Glenn N. Levine, MD, FACC, FAHA, Chair Patrick T. O’Gara, MD, MACC, FAHA, Chair-Elect Jonathan L. Halperin, MD, FACC, FAHA, Immediate Past Chair [‡‡‡][1] Sana M. Al-Khatib, MD, MHS, FACC, FAHA Joshua A. Beckman, MD, MS, FAHA Kim K. Birtcher, PharmD, MS, AACC Biykem Bozkurt, MD, PhD,
Figures & Tables
📖 Papers frequently viewed together
1,937 Citations
16 Authors (Neil J. Stone, ..., Peter W.F. Wilson)
5,888 Citations
201260.39The Lancet
1,812 Citations
#1Bo Kyung Koo (SNU: Seoul National University)H-Index: 17
#2Woo-Young Chung (SNU: Seoul National University)H-Index: 18
Last. Min Kyong Moon (SNU: Seoul National University)H-Index: 22
view all 3 authors...
BACKGROUND Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a noninvasive and simple test for evaluating the endothelial function. There has been sparse evidence on the usefulness of the RH-PAT index (RHI) in predicting future cardiovascular diseases among diabetic patients. METHODS Asymptomatic diabetic patients with albuminuria were selected; their medical history and laboratory findings were evaluated every 3 to 4 months, respectively. The primary outcome was a composite of three-...
4 CitationsSource
#2Gonçalo CordeiroH-Index: 2
Last. Fernando Magro (University of Porto)H-Index: 41
view all 7 authors...
Recently, the gut microbiome has become an important field of interest. Indeed, the microbiome has been associated to numerous drug interactions and it is thought to influence the efficacy of pharmacologic treatments. Although statins are widely prescribed medications, there remains considerable variability in its therapeutic response. In this context, we aimed to investigate how statins modulate the gut microbiome and, reversely, how can the microbiome influence the course of anti-hypercholeste...
6 CitationsSource
A consensus has formed based on epidemiological studies and clinical trials that intervention to reduce low density lipoprotein cholesterol (LDL-C) will reduce cardiovascular disease (CVD) events. ...
4 CitationsSource
#1Maravillas Sánchez Macarro (Universidad Católica San Antonio de Murcia)H-Index: 1
#2Juan Pablo Martínez Rodríguez (Universidad Católica San Antonio de Murcia)H-Index: 1
Last. Francisco Javier López-Román (Universidad Católica San Antonio de Murcia)H-Index: 5
view all 9 authors...
A single-center, randomized, double-blind controlled trial was conducted to assess the efficacy of a food supplement based on a combination of grapefruit, bitter orange, and olive extracts administered for eight weeks (n = 51) versus placebo (n = 45) on reduction of cardiovascular risk in healthy volunteers. Study variables included flow-mediated vasodilation (FMD), blood pressure (BP), lipid profile, thrombotic status, oxidative stress biomarkers, inflammation-related biomarkers, anthropometric...
5 CitationsSource
#1Kate Shafto (UMN: University of Minnesota)H-Index: 2
#2Anuj ShahH-Index: 1
Last. Frances BaxleyH-Index: 1
view all 7 authors...
Background and Objectives Nutrition is a foundation of health, yet there is a deficiency of nutrition training in graduate medical education. The purpose of this feasibility study was to assess the impact of a brief online clinical nutrition course on medical residents' knowledge and attitudes related to the role of nutrition in clinical practice. Methods Medical residents from two institutions took a 3-hour, online, self-paced and interactive clinical nutrition course that reviewed macronutrien...
1 CitationsSource
802 CitationsSource
Abstract Background The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular disease (ASCVD) events. Since publication of these guidelines, multiple randomized controlled trials evaluating nonstatin lipid-modifying medications have been published. Methods We performed a systematic review to assess the magnitude of b...
83 CitationsSource
#1John D. Omura (CDC: Centers for Disease Control and Prevention)H-Index: 8
#2Kathleen B. Watson (CDC: Centers for Disease Control and Prevention)H-Index: 21
Last. Susan A. Carlson (CDC: Centers for Disease Control and Prevention)H-Index: 29
view all 5 authors...
Purpose:The US Preventive Services Task Force recommends that adults at risk for cardiovascular disease (CVD) be offered or referred to intensive behavioral counseling interventions to promote a he...
3 CitationsSource
Abstract Background Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin–kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. Methods We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients wh...
1,073 CitationsSource
Abstract Objectives This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. Background Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. Methods We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan in...
155 CitationsSource
Cited By1903
#1Jan Engvall (Linköping University)H-Index: 29
#1Vahid Rezvanizadeh (Los Angeles Biomedical Research Institute)H-Index: 1
#2Matthew J. Budoff (UCLA: University of California, Los Angeles)H-Index: 138
#1Amy L. Peterson (UW: University of Wisconsin-Madison)H-Index: 5
#2Xiao Zhang (UW: University of Wisconsin-Madison)H-Index: 82
Last. Megan A. Moreno (UW: University of Wisconsin-Madison)H-Index: 34
view all 7 authors...
Abstract null null Conflicting guidelines regarding universal pediatric cholesterol screening were released between 2011 and 2019, but the impact on screening rates remains understudied. The purpose of this study was to examine trends in pediatric cholesterol screening rates within a single institution in the United States and their association with release of national guidelines, local educational tools, and electronic health record (EHR) modifications. Order placement was defined as ordering a...
#1Riyad Yazan Kherallah (BCM: Baylor College of Medicine)H-Index: 1
#2Mahmoud Al Rifai (BCM: Baylor College of Medicine)H-Index: 16
Last. Jaideep Patel (MCV: VCU Medical Center)H-Index: 11
view all 13 authors...
Abstract null null Medication nonadherence is highly prevalent among patients with chronic cardiovascular disease. Poor adherence has been associated with increased morbidity and mortality. Medication cost is a major driver for medication nonadherence. Utilizing data from the 2016 to 2018 Behavioral Risk Factor Surveillance System (BRFSS) survey, we estimated the prevalence of cost-related medication nonadherence (CRMNA) among the overall population and among individuals who reported a history o...
#1Alexandra Galati (UCSF: University of California, San Francisco)
#2E. Sherwood Brown (UTSW: University of Texas Southwestern Medical Center)H-Index: 45
Last. Jeffrey M. Gelfand (UCSF: University of California, San Francisco)H-Index: 37
view all 5 authors...
Abstract null null Given widespread use of glucocorticoid therapy in neurologic disease, understanding glucocorticoid pharmacology and risk is paramount for the practicing neurologist. While dosing and tapering regimens vary depending on the neurological disease and indication being treated, there are important general principles of glucocorticoid prescribing and monitoring that can guide clinical decision-making. Glucocorticoid-related toxicities can occur across multiple organ systems, includi...
#1Massimiliano Ruscica (University of Milan)H-Index: 35
#2Cesare R. Sirtori (University of Milan)H-Index: 72
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 104
view all 5 authors...
Abstract null null Over the last 10 years, there have been advances on several aspects of lipoprotein(a) which are reviewed in the present article. Since the standard immunoassays for measuring lipoprotein(a) are not fully apo(a) isoform-insensitive, the application of an LC-MS/MS method for assaying molar concentrations of lipoprotein(a) has been advocated. Genome wide association, epidemiological, and clinical studies have established high lipoprotein(a) as a causal risk factor for atheroscler...
#1Kazuma Oyama (Brigham and Women's Hospital)H-Index: 3
#2Robert P. Giugliano (Brigham and Women's Hospital)H-Index: 91
Last. Eugene Braunwald (Brigham and Women's Hospital)H-Index: 266
view all 8 authors...
Abstract Background The 2018 U.S. cholesterol management guideline recommends additional lipid-lowering therapy with ezetimibe for secondary prevention in very high-risk patients with low-density l...
1 CitationsSource
#1Jiang He (Tulane University)H-Index: 45
Importance null After decades of decline, the US cardiovascular disease mortality rate flattened after 2010, and racial and ethnic differences in cardiovascular disease mortality persisted. null Objective null To examine 20-year trends in cardiovascular risk factors in the US population by race and ethnicity and by socioeconomic status. null Design, Setting, and Participants null A total of 50 571 participants aged 20 years or older from the 1999-2018 National Health and Nutrition Examination Su...
#1Yingying Li (Peking Union Medical College)
#2Xinyu Ji (Peking Union Medical College)H-Index: 2
Last. Danli Tang (Peking Union Medical College)H-Index: 1
view all 6 authors...
Abstract Ethnopharmacological relevance The gut microbiome plays an important role in advancing the process of host lipid metabolism directly or indirectly. Traditional Chinese medicine (TCM) can improve the intestinal environment by intervening with gut microbiota metabolites to potentially regulate lipid levels. However, the underlying mechanisms remain unclear. Therefore, we examined the current databases to search for studies related to influence of TCM on the gut microbiota metabolites-medi...
#1Shu-Hui Sun (Memorial Hospital of South Bend)
#2Chia-Hsuin Chang (NTU: National Taiwan University)H-Index: 38
view all 6 authors...
Background Several observational studies have found that statins may materially decrease the risk of chronic obstructive pulmonary disease (COPD) exacerbations. However, most of these studies used a prevalent user, non-user comparison approach, which may lead to overestimation of the clinical benefits of statins. We aimed to explore the risk of COPD exacerbations associated with statins with a new user, active comparison approach to address potential methodological concerns. We selected fibrates...