RDNA-04. POTENTIAL MECHANISM OF TEMOZOLOMIDE-MEDIATED RADIO-SENSITIZATION IN MGMT HYPERMETHYLATED GLIOBLASTOMA CELLS

Temozolomide (TMZ) mediated radio-sensitization is preferentially observed in MGMT hypermethylated glioblastoma (GBM) and is modulated by unknown underlying mechanisms. To gain insight into the potential mechanism of TMZ-induced radio-sensitization, we examined the effect of TMZ pre-exposure on the processing of radiation (RT)-induced double strand breaks (DSBs) in an isogenic model, the U251-vector versus U251-MGMT cells derived by the...