Original paper

Single-nucleotide-resolution sequencing of humanN6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

Volume: 46, Issue: 22, Pages: 11659 - 11670
Published: Nov 9, 2018
Abstract
N6-methyldeoxyadenosine (6mA) is a well-characterized DNA modification in prokaryotes but reports on its presence and function in mammals have been controversial. To address this issue, we established the capacity of 6mA-Crosslinking-Exonuclease-sequencing (6mACE-seq) to detect genome-wide 6mA at single-nucleotide-resolution, demonstrating this by accurately mapping 6mA in synthesized DNA and bacterial genomes. Using 6mACE-seq, we generated a...
Paper Details
Title
Single-nucleotide-resolution sequencing of humanN6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome
Published Date
Nov 9, 2018
Volume
46
Issue
22
Pages
11659 - 11670
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