Complement system

Psychology

Complementation

Tau pathology

Immune system

Neurodegeneration

Alzheimer's disease

Complement (music)

Tauopathy

Neuroscience

Disease

Biology

Gene

Phenotype

Pathology

Immunology

Genetics

Medicine

Neuron

Litvinchuk et al. show that complement C3aR plays a critical role in mediating immune homeostasis and tau pathology. The identification of a conserved C3aR network and crosstalk between complement signaling with STAT3 activation reveal novel pathogenic and therapeutic insights.

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease