Obstetrics

Pathology

Fetus

Immunohistochemistry

Placental site trophoblastic tumor

Placenta

Molar pregnancy

Gestational trophoblastic disease

Pregnancy

Trophoblastic neoplasm

Choriocarcinoma

Trophoblastic Tumor

Gestational trophoblastic neoplasia

Gynecology

Gestation

Genetics

Medicine

Biology

Archives of Pathology & Laboratory Medicine

Gestational trophoblastic tumors include 3 distinct entities: gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Accurate diagnosis is important for clinical management of the patient.To review clinical features and pathologic diagnosis of gestational trophoblastic tumors.Literature and personal experience are the sources for this study.Trophoblastic tumors are rare encounters in modern medicine, as a result of clinical practice of molar surveillance programs and early chemotherapeutic intervention for persistent gestational trophoblastic neoplasia. Diagnostic recognition of these tumors requires a high index of suspicion, awareness of their histologic characteristics, and appropriate application of immunohistochemical and molecular biomarkers. Recent attention has been given to a few precursor lesions of gestational trophoblastic tumors, including early/in situ choriocarcinoma and atypical placental site nodule.

Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology