Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
Abstract
Incomplete understanding of the metastatic process hinders personalized therapy. Here we report the most comprehensive whole-genome study of colorectal metastases vs. matched primary tumors. 65% of somatic mutations originate from a common progenitor, with 15% being tumor- and 19% metastasis-specific, implicating a higher mutation rate in metastases. Tumor- and metastasis-specific mutations harbor elevated levels of BRCAness. We confirm...
Paper Details
Title
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
Published Date
Nov 14, 2018
Journal
Volume
9
Issue
1
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