TMIC-22. EXOSOMAL NON-CODING RNAS MEDIATE THE CROSS-TALK OF BRAIN METASTASIS CANCER STEM CELLS AND MICROGLIA

Brain metastases are the most common secondary brain tumors in adults. Despite their high frequency and patient poor prognosis, very little research has been performed on lung tumor brain metastases, mainly due to the lack of appropriate experimental models. In this study, we isolated cancer stem cells (CSCs) from fresh specimens of lung tumor brain metastases. The CSCs were analyzed for sphere formation and limiting dilution analyses, stemness...