Allogeneic hematopoietic stem cell transplantation in adolescent patients with chronic granulomatous disease

Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency caused by functional impairment of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and characterized by recurrent and severe infections, dysregulated inflammation, and autoimmunity. Allogeneic hematopoietic stem cell transplantation (HSCT) can be curative with resolution of both infectious and inflammatory complications. However,...