Differential attenuation of β2 integrin–dependent and –independent neutrophil migration by Ly6G ligation
Abstract
Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on β2 integrins, adhesion molecules that interact with Ly6G at the neutrophil surface. In integrin-dependent murine arthritis, Ly6G ligation attenuated joint inflammation, even though mice lacking Ly6G altogether developed arthritis...
Paper Details
Title
Differential attenuation of β2 integrin–dependent and –independent neutrophil migration by Ly6G ligation
Published Date
Jan 29, 2019
Journal
Volume
3
Issue
3
Pages
256 - 267
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