Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Abstract
Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic ( db/db ) mouse kidneys, demethylation of Tgfb1 DNA and upregulation of Tgfb1 mRNA progressed simultaneously. USF1 binding site in Tgfb1 promoter region were demethylated, and binding of USF1...
Paper Details
Title
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Published Date
Nov 5, 2018
Journal
Volume
8
Issue
1
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