DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.
Abstract
Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the...
Paper Details
Title
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.
Published Date
Nov 1, 2018
Volume
2
Issue
11
Pages
865 - 877
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