Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress

Psoriasis (PsO) is an autoimmune disease characterized by keratinocyte proliferation, chronic inflammation and mast cell activation. Up to 42 % of patients with PsO may present psoriatic arthritis (PsA). PsO and PsA share common pathophysiologic mechanisms: keratinocytes and fibroblast-like synoviocytes are resistant to apoptosis, this is one of the mechanism facilitating their hyperplastic growth, and, at joint level, the destruction of...