Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
Abstract
Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a lung epithelial specific K-ras mutant/ Stat3 conditional knockout (LR/ Stat3 Δ/Δ ) mouse model. Epithelial Stat3 deletion results in intriguing sex-associated discrepancies; K-ras mutant tumors are decreased in female LR/ Stat3...
Paper Details
Title
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
Published Date
Oct 29, 2018
Journal
Volume
9
Issue
1
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