Antibacterial Activity and Biocompatibility of Nanoporous Titanium Doped with Silver Nanoparticles and Coated with N-Acetyl Cysteine

Alkali-treated titanium with nanonetwork structure (TNS) is strongly osteogenic but not antibacterial in nature. In contrast, titanium doped with silver nanoparticles (Ag-NPs) possesses excellent and long-term antibacterial activity, but induces significant levels of intracellular reactive oxygen species that may cause cytotoxicity. We attempted to enhance the antibacterial activity of TNS by doping with Ag-NPs and prevent intracellular reactive...