A0221 Myocardial Proteomic Signatures in End-Stage Dilated and Ischemic Cardiomyopathy Compared with Normal Human Hearts

Objectives: Proteomic studies can provide deeper mechanistic insight in the pathophysiology of heart failure, but those performed on human hearts are scarce. Methods: Using liquid chromatography-tandem mass spectrometry, we analyzed biopsies from explanted human hearts, 15 with ischemic (ICMP) and 14 with dilated (DCMP) cardiomyopathy and 12 healthy donor hearts discarded from implantation (CNT). Results: Compared with CNT, with...