Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

Cell64.50
Volume: 175, Issue: 5, Pages: 1418 - 1429.e9
Published: Nov 1, 2018
Abstract
We report here a simple and global strategy to map out gene functions and target pathways of drugs, toxins, or other small molecules based on "homomer dynamics" protein-fragment complementation assays (hdPCA). hdPCA measures changes in self-association (homomerization) of over 3,500 yeast proteins in yeast grown under different conditions. hdPCA complements genetic interaction measurements while eliminating the confounding effects of gene...
Paper Details
Title
Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics
Published Date
Nov 1, 2018
Journal
Volume
175
Issue
5
Pages
1418 - 1429.e9
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