A new approach to Z‐spectrum acquisition: prospective baseline enhancement (PROBE) for CEST/Nuclear Overhauser Effect

Purpose To develop a prospective baseline enhancement that compensates for intermingled background effects in Z ‐spectra to achieve sensitivity enhancement of peaks related to CEST and nuclear Overhauser effect. Methods An MRI sequence–specific compensation of background effects is achieved through variation of the pulsed saturation power, , with the chemical shift, . After a “scout acquisition” of a standard Z ‐spectrum, the background is...