HLA*LA—HLA typing from linearly projected graph alignments
Abstract
HLA*LA implements a new graph alignment model for human leukocyte antigen (HLA) type inference, based on the projection of linear alignments onto a variation graph. It enables accurate HLA type inference from whole-genome (99% accuracy) and whole-exome (93% accuracy) Illumina data; from long-read Oxford Nanopore and Pacific Biosciences data (98% accuracy for whole-genome and targeted data) and from genome assemblies. Computational requirements...
Paper Details
Title
HLA*LA—HLA typing from linearly projected graph alignments
Published Date
Apr 3, 2019
Journal
Volume
35
Issue
21
Pages
4394 - 4396
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