Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis
Abstract
Macrophages in the healthy intestine are highly specialized and usually respond to the gut microbiota without provoking an inflammatory response. A breakdown in this tolerance leads to inflammatory bowel disease (IBD), but the mechanisms by which intestinal macrophages normally become conditioned to promote microbial tolerance are unclear. Strong epidemiological evidence linking disruption of the gut microbiota by antibiotic use early in life to...
Paper Details
Title
Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis
Published Date
Oct 24, 2018
Volume
10
Issue
464
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