Hyperprogressive disease: recognizing a novel pattern to improve patient management

Volume: 15, Issue: 12, Pages: 748 - 762
Published: Oct 25, 2018
Abstract
Anti-PD-1/PD-L1 monoclonal antibodies have substantially improved the overall survival of a subset of patients across multiple solid tumour types, but other patients can have a deterioration of their disease as a result of such therapies. This paradoxical phenomenon is defined as hyperprogression. In this Review, we present the available evidence of hyperprogressive disease following immune-checkpoint inhibition, the pathophysiological...
Paper Details
Title
Hyperprogressive disease: recognizing a novel pattern to improve patient management
Published Date
Oct 25, 2018
Volume
15
Issue
12
Pages
748 - 762
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