A RNA producing DNA hydrogel as a platform for a high performance RNA interference system
Abstract
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This RNAi-exhibiting gel (termed I-gel for interfering gel) consists of a plasmid carrying the gene transcribing siRNA against the target mRNA as part of the gel scaffold. The RNAi efficiency of the I-gel has been confirmed by green fluorescent...
Paper Details
Title
A RNA producing DNA hydrogel as a platform for a high performance RNA interference system
Published Date
Oct 18, 2018
Journal
Volume
9
Issue
1
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