A dynamic N 6 -methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Abstract
N6-methyladenosine (m6A) on mRNAs is critical for various biological processes, yet whether m6A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase inhibitor (TKI) therapy depends on m6A reduction resulting from FTO overexpression in leukemia cells. This deregulated FTO-m6A axis pre-exists in naive cell populations that are genetically homogeneous and is inducible/reversible in...
Paper Details
Title
A dynamic N 6 -methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Published Date
Oct 8, 2018
Journal
Volume
28
Issue
11
Pages
1062 - 1076
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