O2‐05‐03: BMI CHANGES FROM NORMAL TO OBESE OVER FOUR DECADES PREDICT THINNER CORTICES IN REGIONS RELATED TO ALZHEIMER'S AND RELATED DEMENTIA

Strong evidence suggests that being obese at midlife confers a significantly higher risk for Alzheimer's disease and related dementias in later life (ADRD). Midlife brain structure is also a significant predictor of conversion to ADRD. However, few studies have examined relationships between body mass index (BMI) progression in years prior to midlife and midlife brain structure. Here, we examine the relationship between BMI trajectories from...