Integrated molecular characterization of IDH‐mutant glioblastomas

Aims Mutations of isocitrate dehydrogenase ( IDH )1/2 affect almost all astrocytomas of WHO grade II and III . A subset of IDH ‐mutant astrocytic tumours progresses to IDH ‐mutant glioblastoma or presents with the histology of a glioblastoma at first presentation. We set out here to assess the molecular spectrum of IDH ‐mutant glioblastomas. Methods We performed an integrated molecular analysis of a mono‐centric cohort ( n = 97); assessed...