Insulin Delivery: Erythrocyte-Membrane-Camouflaged Nanoplatform for Intravenous Glucose-Responsive Insulin Delivery (Adv. Funct. Mater. 41/2018)

In article number 1802250 Qing Lin, Ling Zhang, and co-workers report an artificial “closed-loop” structure for intravenous glucose-responsive insulin delivery. An acid-sensitive matrix forms the “inner core” and RBCm-derived coating the “outer shell”. Under hyperglycemic condition, the glucose internalized by the anchored glucose transporters is enzymatically converted into gluconic acid and subsequently triggers acid degradation of the “inner...