Epac1 ^−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast‐enhanced magnetic resonance imaging with contrast agents of different molecular weights

Aim Epac1 −/− mice, but not Epac2 −/− mice have elevated baseline permeability to albumin. This study extends the investigations of how Epac‐dependent pathways modulate transvascular exchange in response to the classical inflammatory agent histamine. It also evaluates the limitations of models of blood‐to‐tissue exchange in transgenic mice in DCE ‐ MRI measurements. Methods We measured DCE ‐ MRI signal intensity in masseter muscle of wt and...