The ORF5 protein of porcine circovirus type 2 enhances viral replication by dampening type I interferon expression in porcine epithelial cells

Identifying the functional role of each porcine circovirus type 2 (PCV2) ORF associated with host cell modulation might provide better knowledge about the pathogenesis of postweaning multisystemic wasting syndrome (PMWS). PCV2 ORF5 was recently identified and the functional role of ORF5 during pathogenesis after PCV2 infection is largely unknown. In this study, we used RNA-seq to investigate the functional role of PCV2 ORF5 in PCV2-infected...