Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Abstract
The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrometry analyses. In vivo proteins are generated from at least two sources: labeled amino acids from the diet, and non-labeled amino acids from the...
Paper Details
Title
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Published Date
Oct 12, 2018
Journal
Volume
9
Issue
1
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