Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations

Published on May 1, 2019in Clinical Oral Investigations2.812
· DOI :10.1007/S00784-018-2637-1
Constanza Martínez12
Estimated H-index: 12
(UC: Pontifical Catholic University of Chile),
Roberto S. Gómez9
Estimated H-index: 9
(UC: Pontifical Catholic University of Chile)
+ 1 AuthorsPatricio C. Smith22
Estimated H-index: 22
(UC: Pontifical Catholic University of Chile)
Objectives Cell-based therapies involve the need to expand cell cultures ex vivo for their subsequent implantation in an autologous manner. An important limitation regarding this technology is the use of fetal bovine serum (FBS) that has critical safety limitations. Platelet-derived fractions represent an autologous source of growth factors that may be used for the expansion of these cell cultures. Periodontal ligament (PDL) cells comprise a heterogeneous cell population that may not necessarily respond in a uniform manner to proliferative stimuli. The aim of this study was to evaluate the ability of two platelet-derived fractions, platelet-rich plasma (PRP) and platelet-poor plasma (PPP) and FBS on the proliferative response of different subpopulations of PDL cell cultures.
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