Tumor microenvironment

Effector

Biology

VEGF receptors

Cytotoxic T cell

In vitro

Immunology

Ramucirumab

Tumor cells

Cancer research

Biochemistry

Medicine

Immune system

Journal for ImmunoTherapy of Cancer

Several studies have established a correlation between the VEGF-VEGFR2 axis and an immunosuppressive microenvironment; this immunosuppression can be overcome by anti-angiogenic reagents, such as ramucirumab (RAM). However, little is known about the immunological impact of anti-angiogenic reagents within the tumor microenvironment in human clinical samples. This study aimed at investigating the effects of RAM on the tumor microenvironmental immune status in human cancers.

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment