Toward the Selection of Sustainable Catalysts for Suzuki–Miyaura Coupling: A Gate-to-Gate Analysis

Reports of homogeneous and heterogeneous methods for Pd-catalyzed Suzuki–Miyaura coupling provide a vast data set to establish sustainability targets and parameters for future catalyst development. In this gate-to-gate inventory we estimate energy and palladium usage along with reaction mass efficiency (RME) for a range of palladium catalysts (both single- and multiuse) for the generation of (a) 4-phenylphenol from 4-iodophenol and phenylboronic...