Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
Abstract
Immunotoxins are proteins containing a cell-targeting element linked to a toxin that are under investigation for next-generation cancer treatment. However, these agents are difficult to synthesize, chemically heterogeneous, expensive, and show toxicity toward healthy cells. In this work, we describe the synthesis and characterization of a new type of immunotoxin that showed exquisite selectivity toward targeted cells. In our construct, targeting...
Paper Details
Title
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
Published Date
Oct 2, 2018
Journal
Volume
13
Issue
11
Pages
3153 - 3160
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Notes
History