Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk

Loss-of-function mutations in the SGLT1 (sodium/glucose co-transporter-1) gene result in a rare glucose/galactose malabsorption disorder and neonatal death if untreated. In the general population, variants related to intestinal glucose absorption remain uncharacterized.The goal of this study was to identify functional SGLT1 gene variants and characterize their clinical consequences.Whole exome sequencing was performed in the ARIC...